The research studied the influence of institutional design on the performance of the agencies in charge of the implementation of access to public information (AI) regulation based on Moe (1989)´s idea of structural politics and the Carpenter (2001) and Wilson (1989)´ concepts of bureaucratic autonomy. The study was conducted under a qualitative methodology and through a multiple case study strategy where two countries were evaluated: Argentina and Mexico. Two variables were analyzed: the institutional design and autonomy of the agencies in charge of the implementation in both countries and their performances. The research found that there is variance in both variables and there is a strong relationship between the institutional design and the performance of the agencies especially in the promotion of the legislation, awareness of the right of AI, and the resolution of controversies between petitioners and regulated agencies.